Editorials
Low Glucocerebrosidase Activity Predicts Dementia in Parkinson Disease: Less Is Not More!
Aldridge CM. Neurology. 2022 Oct 18:10.1212/WNL.0000000000201575. doi: 10.1212/WNL.0000000000201575. Online ahead of print
Cerebrospinal fluid levels of alpha-synuclein in Parkinson’s disease: Another long and winding road.
Markopoulou K, Compta Y.
Parkinsonism Relat Disord. 2018 Apr;49:1-3. doi: 10.1016/j.parkreldis.2018.02.035.
Thoughts on fatigue in Parkinson’s disease (and other disorders).
Friedman JH.
Eur J Neurol. 2017 Jan;24(1):5-6.
β-Amyloid in CSF. A window into Parkinson disease dementia.
Siderowf A, Logroscino G.
Neurology. 2014 Apr 18.
Can Mild Cognitive Impairment in Parkinson Disease Predict the Development of Dementia?
Copeland BJ, Schiess MC.
JAMA Neurol. 2013 Mar 25:1-3.
Parkinson disease: Nonmotor symptoms predict quality of life in patients with early Parkinson disease.
Malkki H.
Nat Rev Neurol. 2013 Oct;9(10):544. doi: 10.1038/nrneurol.2013.176.
The Riddle of Psychiatric Disorders in Parkinson’s Disease: From Phenomenology to Treatment.
Starkstein SE.
Am J Geriatr Psychiatry 20:2, February 2012
Motor deficits associated with changes in β-amyloid in Parkinson’s disease.
Halliday GM.
J Neurol Neurosurg Psychiatry. 2012 Nov 9.
Is fatigue in early Parkinson’s disease a minor inconvenience or major distress? The answer is ‘yes’!
Friedman JH.
Eur J Neurol. 2012 Jul;19(7):931-2.
Not all that goes «bump in the night» is RLS: Leg motor restlessness in PD.
Arnulf I, Morgan J.
Neurology. 2011 Nov;77(22):1936-1937.
Extending MCI beyond Alzheimer disease.
Paulsen JS, Duff K.
Neurology. 2009 Mar;72(13):1116-1117.
Neuropsychiatric disorders in early untreated Parkinson’s disease.
Starkstein SE.
J Neurol Neurosurg Psychiatry. 2009 Aug;80(8).
Publications
2022
Association of CSF Glucocerebrosidase Activity With the Risk of Incident Dementia in Patients With Parkinson Disease.
Oftedal L, Maple-Grødem J, Dalen I, Tysnes OB, Pedersen KF, Alves G, Lange J. Neurology. 2022 Oct 17:10.1212/WNL.0000000000201418. doi: 10.1212/WNL.0000000000201418. Online ahead of print.
PMID: 36253102
Early Forms of α-Synuclein Pathology Are Associated with Neuronal Complex I Deficiency in the Substantia Nigra of Individuals with Parkinson’s Disease.
Flønes IH, Nyland H, Sandnes DA, Alves GW, Tysnes OB, Tzoulis C.
Biomolecules. 2022 May 25;12(6):747. doi: 10.3390/biom12060747.
PMID: 35740871
Frailty in Parkinson’s disease and its association with early dementia: A longitudinal study.
Borda MG, Pérez-Zepeda MU, Jaramillo-Jimenez A, Chaudhuri KR, Tovar-Rios DA, Wallace L, Batzu L, Rockwood K, Tysnes OB, Aarsland D, Alves G. Parkinsonism Relat Disord. 2022 May 13;99:51-57. doi: 10.1016/j.parkreldis.2022.05.004. Online ahead of print.
PMID: 35598420
Parkinson’s disease clinical milestones and mortality.
Gonzalez MC, Dalen I, Maple-Grødem J, Tysnes OB, Alves G. NPJ Parkinsons Dis. 2022 May 12;8(1):58. doi: 10.1038/s41531-022-00320-z.
PMID: 35550520
Ultra-deep whole genome bisulfite sequencing reveals a single methylation hotspot in human brain mitochondrial DNA.
Guitton R, Dölle C, Alves G, Ole-Bjørn T, Nido GS, Tzoulis C. Epigenetics. 2022 Mar 7:1-16. doi: 10.1080/15592294.2022.2045754. Online ahead of print.
PMID: 35253628
GBA and APOE Impact Cognitive Decline in Parkinson’s Disease: A 10-Year Population-Based Study.
Szwedo AA, Dalen I, Pedersen KF, Camacho M, Bäckström D, Forsgren L, Tzoulis C, Winder-Rhodes S, Hudson G, Liu G, Scherzer CR, Lawson RA, Yarnall AJ, Williams-Gray CH, Macleod AD, Counsell CE, Tysnes OB, Alves G, Maple-Grødem J; Parkinson’s Incidence Cohorts Collaboration. Mov Disord. 2022 May;37(5):1016-1027. doi: 10.1002/mds.28932. Epub 2022 Feb 2.
PMID: 35106798
2021
The impact of common genetic variants in cognitive decline in the first seven years of Parkinson’s disease: A longitudinal observational study.
Chung J, Ushakova A, Doitsidou M, Tzoulis C, Tysnes OB, Dalen I, Pedersen KF, Alves G, Maple-Grødem J.Neurosci Lett. 2021 Nov 1;764:136243. doi: 10.1016/j.neulet.2021.136243. Epub 2021 Sep 10.
PMID: 34509566
Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson’s disease.
Liu G, Peng J, Liao Z, Locascio JJ, Corvol JC, Zhu F, Dong X, Maple-Grødem J, Campbell MC, Elbaz A, Lesage S, Brice A, Mangone G, Growdon JH, Hung AY, Schwarzschild MA, Hayes MT, Wills AM, Herrington TM, Ravina B, Shoulson I, Taba P, Kõks S, Beach TG, Cormier-Dequaire F, Alves G, Tysnes OB, Perlmutter JS, Heutink P, Amr SS, van Hilten JJ, Kasten M, Mollenhauer B, Trenkwalder C, Klein C, Barker RA, Williams-Gray CH, Marinus J; International Genetics of Parkinson Disease Progression (IGPP) Consortium, Scherzer CR. Nat Genet. 2021 Jun;53(6):787-793. doi: 10.1038/s41588-021-00847-6. Epub 2021 May 6.
PMID: 33958783
Letter to the editor in response to the letter from the EPIPARK Study Group regarding the publication ‘Progression of fatigue in Parkinson’s disease – a 9-year follow-up’ (Eur J Neurol 2021. doi:10.1111/ene.14520).
Ongre SO, Dalen I, Tysnes OB, Alves G, Herlofson K. Eur J Neurol. 2021 Jun;28(6):e33-e34. doi: 10.1111/ene.14765. Epub 2021 Feb 23. PMID: 33547699
Early constipation predicts faster dementia onset in Parkinson’s disease.
Camacho M, Macleod AD, Maple-Grødem J, Evans JR, Breen DP, Cummins G, Wijeyekoon RS, Greenland JC, Alves G, Tysnes OB, Lawson RA, Barker RA, Williams-Gray CH. NPJ Parkinsons Dis. 2021 May 26;7(1):45. doi: 10.1038/s41531-021-00191-w.
PMID: 34039994
Genome-wide histone acetylation analysis reveals altered transcriptional regulation in the Parkinson’s disease brain.
Toker L, Tran GT, Sundaresan J, Tysnes OB, Alves G, Haugarvoll K, Nido GS, Dölle C, Tzoulis C. Mol Neurodegener. 2021 May 5;16(1):31. doi: 10.1186/s13024-021-00450-7.
PMID: 33947435
Lack of Association Between GBA Mutations and Motor Complications in European and American Parkinson’s Disease Cohorts.
Maple-Grødem J, Paul KC, Dalen I, Ngo KJ, Wong D, Macleod AD, Counsell CE, Bäckström D, Forsgren L, Tysnes OB, Kusters CDJ, Fogel BL, Bronstein JM, Ritz B, Alves G. J Parkinsons Dis. 2021;11(4):1569-1578. doi: 10.3233/JPD-212657.
PMID: 34275908
Association of SNCA Parkinson’s Disease Risk Polymorphisms With Disease Progression in Newly Diagnosed Patients.
Szwedo AA, Pedersen CC, Ushakova A, Forsgren L, Tysnes OB, Counsell CE, Alves G, Lange J, Macleod AD, Maple-Grødem J.Front Neurol. 2021 Feb 10;11:620585. doi: 10.3389/fneur.2020.620585. eCollection 2020.
PMID: 33643180
Association of GBA Genotype With Motor and Functional Decline in Patients With Newly Diagnosed Parkinson Disease.
Maple-Grødem J, Dalen I, Tysnes OB, Macleod AD, Forsgren L, Counsell CE, Alves G. Neurology. 2021 Feb 16;96(7):e1036-e1044. doi: 10.1212/WNL.0000000000011411. Epub 2020 Dec 21.
PMID: 33443131
2020
Differential transcript usage in the Parkinson’s disease brain.
Dick F, Nido GS, Alves GW, Tysnes OB, Nilsen GH, Dölle C, Tzoulis C.
PLoS Genet. 2020 Nov 2;16(11):e1009182. doi: 10.1371/journal.pgen.1009182. eCollection 2020 Nov.
PMID: 33137089
Differences in the Presentation and Progression of Parkinson’s Disease by Sex.
Iwaki H, Blauwendraat C, Leonard HL, Makarious MB, Kim JJ, Liu G, Maple-Grødem J, Corvol JC, Pihlstrøm L, van Nimwegen M, Smolensky L, Amondikar N, Hutten SJ, Frasier M, Nguyen KH, Rick J, Eberly S, Faghri F, Auinger P, Scott KM, Wijeyekoon R, Van Deerlin VM, Hernandez DG, Gibbs RJ, Day-Williams AG, Brice A, Alves G, Noyce AJ, Tysnes OB, Evans JR, Breen DP, Estrada K, Wegel CE, Danjou F, Simon DK, Andreassen OA, Ravina B, Toft M, Heutink P, Bloem BR, Weintraub D, Barker RA, Williams-Gray CH, van de Warrenburg BP, Van Hilten JJ, Scherzer CR, Singleton AB, Nalls MA.Mov Disord. 2020 Oct 1. doi: 10.1002/mds.28312. Online ahead of print.
PMID: 33002231
Meta-analysis of whole-exome sequencing data from two independent cohorts finds no evidence for rare variant enrichment in Parkinson disease associated loci.
Gaare JJ, Nido G, Dölle C, Sztromwasser P, Alves G, Tysnes OB, Haugarvoll K, Tzoulis C.
PLoS One. 2020 Oct 1;15(10):e0239824. doi: 10.1371/journal.pone.0239824. eCollection 2020.
PMID: 33002040
Progression of fatigue in Parkinson’s disease – a 9-year follow-up.
Ongre SO, Dalen I, Tysnes OB, Alves G, Herlofson K.
Eur J Neurol. 2020 Sep 13. doi: 10.1111/ene.14520. Online ahead of print.
PMID: 32920893
Impulsive and compulsive behaviors in Parkinson’s disease: Impact on quality of and satisfaction with life, and caregiver burden.
Erga AH, Alves G, Tysnes OB, Pedersen KF.
Parkinsonism Relat Disord. 2020 Jul 9;78:27-30. doi: 10.1016/j.parkreldis.2020.07.007.
PMID: 32679528
Genetic risk scores and hallucinations in patients with Parkinson disease.
Kusters CDJ, Paul KC, Duarte Folle A, Keener AM, Bronstein JM, Dobricic V, Tysnes OB, Bertram L, Alves G, Sinsheimer JS, Lill CM, Maple-Grødem J, Ritz BR.
Neurol Genet. 2020 Jul 20;6(5):e492. doi: 10.1212/NXG.0000000000000492. eCollection 2020 Oct.
PMID: 32802953
Validation of a UPDRS-/MDS-UPDRS-based definition of functional dependency for Parkinson’s disease.
Ramsay N, Macleod AD, Alves G, Camacho M, Forsgren L, Lawson RA, Maple-Grødem J, Tysnes OB, Williams-Gray CH, Yarnall AJ, Counsell CE; Parkinson’s Incidence Cohorts Collaboration; PINE Study; CamPaIGN study; PICNICS study; NYPUM Study; ParkWest Study: ParkWest Principal investigators; Study personnel; ICICLE-PD Study.
Parkinsonism Relat Disord. 2020 May 30;76:49-53. doi: 10.1016/j.parkreldis.2020.05.034. Online ahead of print.
PMID: 32645619
Common gene expression signatures in Parkinson’s disease are driven by changes in cell composition.
Nido GS, Dick F, Toker L, Petersen K, Alves G, Tysnes OB, Jonassen I, Haugarvoll K, Tzoulis C.
Acta Neuropathol Commun. 2020 Apr 21;8(1):55. doi: 10.1186/s40478-020-00932-7.
PMID: 32317022
2019
Evolution of impulsive-compulsive behaviors and cognition in Parkinson’s disease.
Erga AH, Alves G, Tysnes OB, Pedersen KF.
J Neurol. 2019 Oct 18. doi: 10.1007/s00415-019-09584-7. [Epub ahead of print]
PMID: 31628533
Orthostatic hypotension in Parkinson disease: A 7-year prospective population-based study.
Hiorth YH, Pedersen KF, Dalen I, Tysnes OB, Alves G.
Neurology. 2019 Sep 16. pii: 10.1212/WNL.0000000000008314. doi: 10.1212/WNL.0000000000008314.
PMID: 31527282
Genomewide association study of Parkinson’s disease clinical biomarkers in 12 longitudinal patients’ cohorts.
Iwaki H, Blauwendraat C, Leonard HL, Kim JJ, Liu G, Maple-Grødem J, Corvol JC, Pihlstrøm L, van Nimwegen M, Hutten SJ, Nguyen KH, Rick J, Eberly S, Faghri F, Auinger P, Scott KM, Wijeyekoon R, Van Deerlin VM, Hernandez DG, Gibbs JR; International Parkinson’s Disease Genomics Consortium, Chitrala KN, Day-Williams AG, Brice A, Alves G, Noyce AJ, Tysnes OB, Evans JR, Breen DP, Estrada K, Wegel CE, Danjou F, Simon DK, Andreassen O, Ravina B, Toft M, Heutink P, Bloem BR, Weintraub D, Barker RA, Williams-Gray CH, van de Warrenburg BP, Van Hilten JJ, Scherzer CR, Singleton AB, Nalls MA.
Mov Disord. 2019 Sep 10. doi: 10.1002/mds.27845.
PMID: 31505070
Genetic risk of Parkinson disease and progression:: An analysis of 13 longitudinal cohorts.
Iwaki H, Blauwendraat C, Leonard HL, Liu G, Maple-Grødem J, Corvol JC, Pihlstrøm L, van Nimwegen M, Hutten SJ, Nguyen KH, Rick J, Eberly S, Faghri F, Auinger P, Scott KM, Wijeyekoon R, Van Deerlin VM, Hernandez DG, Day-Williams AG, Brice A, Alves G, Noyce AJ, Tysnes OB, Evans JR, Breen DP, Estrada K, Wegel CE, Danjou F, Simon DK, Ravina B, Toft M, Heutink P, Bloem BR, Weintraub D, Barker RA, Williams-Gray CH, van de Warrenburg BP, Van Hilten JJ, Scherzer CR, Singleton AB, Nalls MA.
Neurol Genet. 2019 Jul 9;5(4):e348. doi: 10.1212/NXG.0000000000000348. eCollection 2019 Aug. Erratum in: Neurol Genet. 2019 Aug 15;5(4):e354.
PMID: 31404238
Combinatory microRNA serum signatures as classifiers of Parkinson’s disease.
Patil KS, Basak I, Dalen I, Hoedt E, Lange J, Lunde KA, Liu Y, Tysnes OB, Forsgren L, Aarsland D, Neubert TA, Larsen JP, Alves G, Møller SG.
Parkinsonism Relat Disord. 2019 Apr 11. pii: S1353-8020(19)30205-6. doi: 10.1016/j.parkreldis.2019.04.010.
PMID: 31003905
The value of cerebrospinal fluid α-synuclein and the tau/α-synuclein ratio for diagnosis of neurodegenerative disorders with Lewy pathology.
Førland MG, Tysnes OB, Aarsland D, Maple-Grødem J, Pedersen KF, Alves G, Lange J.
Eur J Neurol. 2019 Jul 10. doi: 10.1111/ene.14032.
PMID: 31293044
2018
A paradoxical relationship between family history, onset age, and genetic risk in Parkinson’s disease.
Kristiansen M, Maple-Grødem J, Alves G, Arepalli S, Hernandez DG, Iwaki H, Nalls MA, Singleton A, Tysnes OB, Toft M, Pihlstrøm L.
Mov Disord. 2019 Feb;34(2):298-299.
PMID: 30484896
Inflammation and fatigue in early, untreated Parkinson’s Disease.
Herlofson K, Heijnen CJ, Lange J, Alves G, Tysnes OB, Friedman JH, Fagundes CP.
Acta Neurol Scand. 2018 Nov;138(5):394-399. doi: 10.1111/ane.12977. Epub 2018 Jun 26.
PMID: 29947088
Rare genetic variation in mitochondrial pathways influences the risk for Parkinson’s disease.
Gaare JJ, Nido GS, Sztromwasser P, Knappskog PM, Dahl O, Lund-Johansen M, Maple-Grødem J, Alves G, Tysnes OB, Johansson S, Haugarvoll K, Tzoulis C.
Mov Disord. 2018 Oct;33(10):1591-1600. doi: 10.1002/mds.64. Epub 2018 Sep 5.
PMID: 30256453
Association of glucocerebrosidase polymorphisms and mutations with dementia in incident Parkinson’s disease.
Lunde KA, Chung J, Dalen I, Pedersen KF, Linder J, Domellöf ME, Elgh E, Macleod AD, Tzoulis C, Larsen JP, Tysnes OB, Forsgren L, Counsell CE, Alves G, Maple-Grødem J.
Alzheimers Dement. 2018 Oct;14(10):1293-1301. doi: 10.1016/j.jalz.2018.04.006. Epub 2018 May 21.
PMID: 29792872
Is psychosis associated with impulse control disorders in Parkinson’s disease?
Erga AH, Bjørnestad A, Tysnes OB, Alves G, Pedersen KF.
Parkinsonism Relat Disord. 2018 Aug;53:110-111. doi: 10.1016/j.parkreldis.2018.04.026. Epub 2018 May 2.
PMID: 29735273
Hyposmia in a simple smell test is associated with accelerated cognitive decline in early Parkinson’s disease.
Gjerde KV, Müller B, Skeie GO, Assmus J, Alves G, Tysnes OB.
Acta Neurol Scand. 2018 Jul 30. doi: 10.1111/ane.13003. [Epub ahead of print]
PMID: 30058142
Alzheimer disease associated variants in SORL1 accelerate dementia development in Parkinson disease.
Maple-Grødem J, Chung J, Lunde KA, Tzoulis C, Tysnes OB, Pedersen KF, Alves G.
Neurosci Lett. 2018 Mar 19;674:123-126.
PMID:2956742
Dopaminergic and Opioid Pathways Associated with Impulse Control Disorders in Parkinson’s Disease.
Erga AH, Dalen I, Ushakova A, Chung J, Tzoulis C, Tysnes OB, Alves G, Pedersen KF, Maple-Grødem J.
Front Neurol. 2018 Feb 28;9:109.
PMID:29541058
Evolution of cerebrospinal fluid total α-synuclein in Parkinson’s disease.
Førland MG, Öhrfelt A, Dalen I, Tysnes OB, Blennow K, Zetterberg H, Pedersen KF, Alves G, Lange J.
Parkinsonism Relat Disord. 2018 Apr;49:4-8.
PMID:29409704
No evidence for rare TRAP1 mutations influencing the risk of idiopathic Parkinson’s disease.
Gaare JJ, Nido GS, Sztromwasser P, Knappskog PM, Dahl O, Lund-Johansen M, Alves G, Tysnes OB, Johansson S, Haugarvoll K, Tzoulis C.
Brain. 2018 Jan 24.
PMID: 29373637
Neuronal complex I deficiency occurs throughout the Parkinson’s disease brain, but is not associated with neurodegeneration or mitochondrial DNA damage.
Flønes IH, Fernandez-Vizarra E, Lykouri M, Brakedal B, Skeie GO, Miletic H, Lilleng PK, Alves G, Tysnes OB, Haugarvoll K, Dölle C, Zeviani M, Tzoulis C.
Acta Neuropathol. 2018 Mar;135(3):409-425.
PMID: 29270838
Ultradeep mapping of neuronal mitochondrial deletions in Parkinson’s disease.
Nido GS, Dölle C, Flønes I, Tuppen HA, Alves G, Tysnes OB, Haugarvoll K, Tzoulis C.
Neurobiol Aging. 2018 Mar;63:120-127.
PMID: 29257976
Development and validation of prognostic survival models in newly diagnosed Parkinson’s disease.
Macleod AD, Dalen I, Tysnes OB, Larsen JP, Counsell CE.
Mov Disord. 2018 Jan;33(1):108-116.
PMID: 28976022
2017
The natural history of depressive symptoms in patients with incident Parkinson’s disease: a prospective cohort study.
Larsen JP, Dalen I, Pedersen KF, Tysnes OB.
J Neurol. 2017 Dec;264(12):2401-2408.
PMID: 29032408
The GBA variant E326K is associated with Parkinson’s disease and explains a genome-wide association signal.
Berge-Seidl V, Pihlstrøm L, Maple-Grødem J, Forsgren L, Linder J, Larsen JP, Tysnes OB, Toft M.
Neurosci Lett. 2017 Sep 29;658:48-52.
PMID: 28830825
Clinical milestones in Parkinson’s disease: A 7-year population-based incident cohort study.
Bjornestad, Pedersen, Tysnes OB, Alves G.
Parkinsonism Relat Disord. 2017 May 29. pii: S1353-8020(17)30191-8. doi: 10.1016/j.parkreldis.2017.05.025.
Is fatigue associated with cognitive dysfunction in early Parkinson’s disease?
Kluger BM, Pedersen KF, Tysnes OB, Ongre SO, Øygarden B, Herlofson K.
Parkinsonism Relat Disord. 2017 Feb 7. pii: S1353-8020(17)30040-8. doi: 10.1016/j.parkreldis.2017.02.005.
Natural course of mild cognitive impairment in Parkinson disease: A 5-year population-based study.
Pedersen KF, Larsen JP, Tysnes OB, Alves G.
Neurology. 2017 Jan 20. pii: 10.1212/WNL.0000000000003634.
2016
Long-term risk of falls in an incident Parkinson’s disease cohort: the Norwegian ParkWest study.
Hiorth YH, Alves G, Larsen JP, Schulz J, Tysnes OB, Pedersen KF.
J Neurol. 2016 Dec 20. doi: 10.1007/s00415-016-8365-z.
PMID: 28000003
Changes in insomnia subtypes in early Parkinson disease.
Tholfsen LK, Larsen JP, Schulz J, Tysnes OB, Gjerstad MD.
Neurology. 2016 Dec 16. pii: 10.1212/WNL.0000000000003540.
PMID: 27986876
Impulsive and Compulsive Behaviors in Parkinson Disease: The Norwegian ParkWest Study.
Erga AH, Alves G, Larsen JP, Tysnes OB, Pedersen KF.
J Parkinsons Dis. 2016 Nov 30.
PMID: 27911342
Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease.
Dölle C, Flønes I, Nido GS, Miletic H, Osuagwu N, Kristoffersen S, Lilleng PK, Larsen JP, Tysnes OB, Haugarvoll K, Bindoff LA, Tzoulis C.
Nat Commun. 2016 Nov 22;7:13548. doi: 10.1038/ncomms13548.
PMID: 27874000
Familial aggregation of Parkinson’s disease may affect progression of motor symptoms and dementia.
Gaare JJ, Skeie GO, Tzoulis C, Larsen JP, Tysnes OB.
Mov Disord. 2016 Nov 10. doi: 10.1002/mds.26856. Review.
PMID: 27862270
Measuring Life Satisfaction in Parkinson’s Disease and Healthy Controls Using the Satisfaction With Life Scale.
Løvereide L, Hagell P.
PLoS One. 2016 Oct 24;11(10):e0163931. doi: 10.1371/journal.pone.0163931.
PMID: 27776131
Fatigue in early Parkinson’s disease: the Norwegian ParkWest study.
Ongre SO, Larsen JP, Tysnes OB, Herlofson K.
Eur J Neurol. 2016 Sep 26. doi: 10.1111/ene.13161.
PMID: 27670392
Loss of independence in early Parkinson disease: A 5-year population-based incident cohort study.
Bjornestad A, Tysnes OB, Larsen JP, Alves G.
Neurology. 2016 Oct 11;87(15):1599-1606.
PMID: 27590290
Validation of a new assay for α-synuclein detection in cerebrospinal fluid.
Førland MG, Öhrfelt A, Oftedal LS, Tysnes OB, Larsen JP, Blennow K, Zetterberg H, Alves G, Lange J.
Clin Chem Lab Med. 2016 Jul 30. pii: /j/cclm.ahead-of-print/cclm-2016-0409/cclm-2016-0409.xml. doi: 10.1515/cclm-2016-0409.
PMID: 27474841
Reliability of Three Disability Scales for Detection of Independence Loss in Parkinson’s Disease.
Bjornestad A, Tysnes OB, Larsen JP, Alves G.
Parkinsons Dis. 2016;2016:1941034. doi: 10.1155/2016/1941034.
PMID: 27213080
Impact of Falls on Physical Activity in People with Parkinson’s Disease.
Hiorth YH, Larsen JP, Lode K, Tysnes OB, Godfrey A, Lord S, Rochester L, Pedersen KF.
J Parkinsons Dis. 2016;6(1):175-82. doi: 10.3233/JPD-150640.
PMID: 26639446
Risk and course of motor complications in a population-based incident Parkinson’s disease cohort.
Bjornestad A, Forsaa EB, Pedersen KF, Tysnes OB, Larsen JP, Alves G.
Parkinsonism Relat Disord. 2016 Jan;22:48-53. doi: 10.1016/j.parkreldis.2015.11.007.
PMID: 26585090
2015
Association of a BACE1 Gene Polymorphism with Parkinson’s Disease in a Norwegian Population.
Lange J, Lunde KA, Sletten C, Møller SG, Tysnes OB, Alves G, Larsen JP, Maple-Grødem J.
Parkinsons Dis. 2015;2015:973298. doi: 10.1155/2015/973298. Epub 2015 Dec 14.
PMID: 26788404
The role of TREM2 R47H as a risk factor for Alzheimer’s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson’s disease.
Lill CM, Rengmark A, Pihlstrøm L, Fogh I, Shatunov A, Sleiman PM, Wang LS, Liu T, Lassen CF, Meissner E, Alexopoulos P, Calvo A, Chio A, Dizdar N, Faltraco F, Forsgren L, Kirchheiner J, Kurz A, Larsen JP, Liebsch M, Linder J, Morrison KE, Nissbrandt H, Otto M, Pahnke J, Partch A, Restagno G, Rujescu D, Schnack C, Shaw CE, Shaw PJ, Tumani H, Tysnes OB, Valladares O, Silani V, van den Berg LH, van Rheenen W, Veldink JH, Lindenberger U, Steinhagen-Thiessen E; SLAGEN Consortium, Teipel S, Perneczky R, Hakonarson H, Hampel H, von Arnim CA, Olsen JH, Van Deerlin VM, Al-Chalabi A, Toft M, Ritz B, Bertram L.
Alzheimers Dement. 2015 Apr 30.
Development of excessive daytime sleepiness in early Parkinson disease.
Tholfsen LK, Larsen JP, Schulz J, Tysnes OB, Gjerstad MD.
Neurology. 2015 Jul 14;85(2):162-8.
HTRA2 p.G399S in Parkinson disease, essential tremor, and tremulous cervical dystonia.
Tzoulis C, Zayats T, Knappskog PM, Müller B, Larsen JP, Tysnes OB, Bindoff LA, Johansson S, Haugarvoll K.
Proc Natl Acad Sci U S A. 2015 May 5;112(18):E2268.
Fine mapping and resequencing of the PARK16 locus in Parkinson’s disease.
Pihlstrøm L, Rengmark A, Bjørnarå KA, Dizdar N, Fardell C, Forsgren L, Holmberg B, Larsen JP, Linder J, Nissbrandt H, Tysnes OB, Dietrichs E, Toft M.
J Hum Genet. 2015 Jul;60(7):357-62.
2014
The factor structure of the UPDRS motor scores changes during early Parkinson’s disease.
Brakedal B, Tysnes OB, Skeie GO, Larsen JP, Müller B.
Parkinsonism Relat Disord. 2014 Jun;20(6):617-21.
CSF Aβ42 predicts early-onset dementia in Parkinson disease.
Alves G, Lange J, Blennow K, Andreasson U, Førland M, Tysnes OB, Larsen JP, Pedersen KF.
Neurology. 2014 Apr 18.
2013
Importance of motor vs. non-motor symptoms for health-related quality of life in early Parkinson’s disease.
Müller B, Assmus J, Herlofson K, Larsen JP, Tysnes OB.
Parkinsonism Relat Disord. 2013 Aug 2.
Prognosis of Mild Cognitive Impairment in Early Parkinson Disease: The Norwegian ParkWest Study.
Pedersen KF, Larsen JP, Tysnes OB, Alves G.
JAMA Neurol. 2013 Mar 25:1-7.
Cerebrospinal fluid Aβ levels correlate with structural brain changes in Parkinson’s disease.
Beyer MK, Alves G, Hwang KS, Babakchanian S, Bronnick KS, Chou YY, Dalaker TO, Kurz MW, Larsen JP, Somme JH, Thompson PM, Tysnes OB, Apostolova LG.
Mov Disord. 2013 Mar;28(3):302-10. doi: 10.1002/mds.25282.
Verbal memory is associated with structural hippocampal changes in newly diagnosed Parkinson’s disease.
Beyer MK, Bronnick KS, Hwang KS, Bergsland N, Tysnes OB, Larsen JP, Thompson PM, Somme JH, Apostolova LG.
J Neurol Neurosurg Psychiatry. 2013 Jan;84(1):23-8.
Supportive evidence for 11 loci from genome-wide association studies in Parkinson’s disease.
Pihlstrøm L, Axelsson G, Bjørnarå KA, Dizdar N, Fardell C, Forsgren L, Holmberg B, Larsen JP, Linder J, Nissbrandt H, Tysnes OB, Ohman E, Dietrichs E, Toft M.
Neurobiol Aging. 2013 Jun;34(6):1708.e7-13.
Cerebrospinal fluid amyloid-β and phenotypic heterogeneity in de novo Parkinson’s disease.
Alves G, Pedersen KF, Bloem BR, Blennow K, Zetterberg H, Borm GF, Dalaker TO, Beyer MK, Aarsland D, Andreasson U, Lange J, Tysnes OB, Zivadinov R, Larsen JP.
J Neurol Neurosurg Psychiatry. 2013 May;84(5):537-43.
Autonomic symptoms and dopaminergic treatment in de novo Parkinson’s disease.
Müller B, Assmus J, Larsen JP, Haugarvoll K, Skeie GO, Tysnes OB.
Acta Neurol Scand. 2013 Apr;127(4):290-4.23.
Parkinson disease: Associated disorders in the Norwegian population based incident ParkWest study.
Skeie GO, Muller B, Haugarvoll K, Larsen JP, Tysnes OB.
Parkinsonism Relat Disord.2013 Jan;19(1):53-5.
Frequencies of falls and associated features at different stages of Parkinson’s disease.
Hiorth YH, Lode K, Larsen JP.
Eur J Neurol. 2013 Jan;20(1):160-6.
Treatment in early Parkinson’s disease: the Norwegian ParkWest study.
Tveiten OV, Skeie GO, Haugarvoll K, Müller B, Larsen JP, Tysnes OB.
Acta Neurol Scand. 2013 Aug;128(2):107-13.
2012
Number of CAG repeats in POLG1 and its association with Parkinson disease in the Norwegian population.
Balafkan N, Tzoulis C, Müller B, Haugarvoll K, Tysnes OB, Larsen JP, Bindoff LA.
Mitochondrion. 2012 Nov;12(6):640-3.
Psychometric Properties of the Starkstein Apathy Scale in Patients With Early Untreated Parkinson Disease.
Pedersen KF, Alves G, Larsen JP, Tysnes OB, Møller SG, Brønnick K.
Am J Geriatr Psychiatry. 2012 Feb;20(2):142-8.
Subjective sleep problems in patients with early Parkinson’s disease.
Stefansdottir S, Gjerstad MD, Tysnes OB, Larsen JP.
Eur J Neurol. 2012 Dec;19(12):1575-81.
Fatigue in early Parkinson’s disease. Minor inconvenience or major distress?
Herlofson K, Ongre SO, Enger LK, Tysnes OB, Larsen JP.
Eur J Neurol. 2012 Jul;19(7):963-8.
Psychometric Properties of the Starkstein Apathy Scale in Patients With Early Untreated Parkinson Disease.
Pedersen KF, Alves G, Larsen JP, Tysnes OB, Møller SG, Brønnick K.
Am J Geriatr Psychiatry. 2012 Feb;20(2):142-8.
2011
Increased risk of leg motor restlessness but not RLS in early Parkinson disease.
Gjerstad MD, Tysnes OB, Larsen JP.
Neurology. 2011 Nov 29;77(22):1941-6.
Ventricular enlargement and mild cognitive impairment in early Parkinson’s disease.
Dalaker TO, Zivadinov R, Ramasamy DP, Beyer MK, Alves G, Bronnick KS, Tysnes OB, Aarsland D, Larsen JP.
Mov Disord. 2011 Feb 1;26(2):297-301.
Verbal memory in drug-naive, newly diagnosed parkinson’s disease. The retrieval deficit hypothesis revisited.
Brønnick K, Alves G, Aarsland D, Tysnes OB, Larsen JP.
Neuropsychology. 2011 Jan;25(1):114-24.
Autonomic and sensory symptoms and signs in incident, untreated Parkinson’s disease: Frequent but mild.
Müller B, Larsen JP, Wentzel-Larsen T, Skeie GO, Tysnes OB; for The ParkWest Study Group.
Mov Disord. 2011 Jan;26(1):65-72.
2010
Mild cognitive impairment in Parkinson disease: a multicenter pooled analysis.
Aarsland D, Bronnick K, Williams-Gray C, Weintraub D, Marder K, Kulisevsky J, Burn D, Barone P, Pagonabarraga J, Allcock L, Santangelo G, Foltynie T, Janvin C, Larsen JP, Barker RA, Emre M.
Neurology. 2010 Sep 21;75(12):1062-9.
Differential effect of environmental risk factors on postural instability gait difficulties and tremor dominant Parkinson’s disease.
Skeie GO, Muller B, Haugarvoll K, Larsen JP, Tysnes OB.
Mov Disord. 2010 Sep 15;25(12):1847-52.
Are dysautonomic and sensory symptoms present in early Parkinson’s disease?
Tysnes OB, Müller B, Larsen JP.
Acta Neurol Scand Suppl. 2010;(190):72-7.
CSF amyloid-{beta} and tau proteins, and cognitive performance, in early and untreated Parkinson’s Disease: the Norwegian ParkWest study.
Alves G, Brønnick K, Aarsland D, Blennow K, Zetterberg H, Ballard C, Kurz MW, Andreasson U, Tysnes OB, Larsen JP, Mulugeta E.
J Neurol Neurosurg Psychiatry. 2010 Oct;81(10):1080-6.
“The role of APOE alleles in newly diagnosed PD patients in Western Norway. The Norwegian ParkWest study”.
Vefring H, Haugarvoll K, Tysnes OB, Larsen JP, Kurz MW; for the Norwegian ParkWest Study group.
Acta Neurol Scand. 2010 Dec;122(6):438-41.
Gray matter correlations of cognition in incident Parkinson’s disease.
Dalaker TO, Zivadinov R, Larsen JP, Beyer MK, Cox JL, Alves G, Bronnick K, Tysnes OB, Antulov R, Dwyer MG, Aarsland D.
Mov Disord. 2010 Apr 15;25(5):629-33.
Caregiver distress associated with neuropsychiatric problems in patients with early Parkinson’s disease: the Norwegian ParkWest study.
Leiknes I, Tysnes OB, Aarsland D, Larsen JP.
Acta Neurol Scand. 2010 Dec;122(6):418-24.
Apathy in drug-naïve patients with incident Parkinson’s disease: the Norwegian ParkWest study.
Pedersen KF, Alves G, Brønnick K, Aarsland D, Tysnes OB, Larsen JP.
J Neurol. 2010 Feb;257(2):217-23.
2009
Health state values during the first year of drug treatment in early-stage Parkinson’s disease: a prospective, population-based, cohort study.
Vossius C, Nilsen OB, Larsen JP.
Drugs Aging. 2009;26(11):973-80.
“Brain Atrophy and White Matter Hyperintensities in Early Parkinson’s Disease. The Norwegian ParkWest study”.
Dalaker TO, Larsen JP, Bergsland N, Beyer MK, Alves G, Dwyer MG, Tysnes OB, Benedict RH, Kelemen A, Bronnick K, Zivadinov R.
Mov Disord. 2009 Nov 15;24(15):2233-41.
White matter hyperintensities do not impact cognitive function in patients with newly diagnosed Parkinson’s disease.
Dalaker TO, Larsen JP, Dwyer MG, Aarsland D, Beyer MK, Alves G, Bronnick K, Tysnes OB, Zivadinov R.
Neuroimage. 2009 Oct 1;47(4):2083-9.
The spectrum of neuropsychiatric symptoms in patients with early untreated Parkinson’s disease.
Aarsland D, Brønnick K, Alves G, Tysnes OB, Pedersen KF, Ehrt U, Larsen JP.
J Neurol Neurosurg Psychiatry. 2009 Aug;80(8):928-30.
Incidence of Parkinson’s disease in Norway: the Norwegian ParkWest study.
Alves G, Müller B, Herlofson K, HogenEsch I, Telstad W, Aarsland D, Tysnes OB, Larsen JP.
J Neurol Neurosurg Psychiatry. 2009 Aug;80(8):851-7.
Cognitive impairment in incident, untreated Parkinson disease: the Norwegian ParkWest study.
Aarsland D, Brønnick K, Larsen JP, Tysnes OB, Alves G; Norwegian ParkWest Study Group.
Neurology. 2009 Mar 31;72(13):1121-6.